1680P Feasibility of home-based supervised physical activity (SPA) for metastatic cancer patients receiving oral targeted therapy: The AFSOS-Unicancer QUALIOR randomized phase II study

If physical activity is already systematically proposed as part of supportive care in localized cancer patients, the implementation for metastatic patients remains a challenge. QUALIOR 2-part, randomized, open-label, multicenter trial which aims to assess feasibility and efficacy supervised home-based SPA receiving oral targeted therapy (phase II: n=120; phase III: n=256). The results II study are presented here. Patients were randomized 2:1 ratio 3-month (experimental arm) or recommended adapted (control arm). was assessed using rate that participated adequately SPA. participation considered sufficient if 45 more performed at least 50% theoretically planned sessions within 3 months (i.e. one home session with sport specialized coach 2 non-supervised per week). Efficacy endpoint fatigue FACT-F questionnaire baseline, every month during then first year follow-up. analysis an intent-to-treat (ITT) analysis. Between 2017 2020, 129 randomized. Among 112 ITT population (74 arm 38 control arm), mean age 59 (sd 13) main site breast (n=64, 57%). Targeted associated hormone-therapy (61%) arm, versus 17 (45%) arm. In sessions, 27 (36%) less than only did not perform any activity. One hundred (89%) completed baseline questionnaire. At 3-month, scores 38.8 10) 36.7 respectively. showed feasible among treated therapy. still ongoing.